The Development of Therapeutics for Pre-Eclampsia

Placental-Specific sFLT-1 e15a Protein Is Increased in Preeclampsia, Antagonizes Vascular Endothelial Growth Factor Signaling, and Has Antiangiogenic Activity

KR Palmer, TJ Kaitu'u-Lino, R Hastie, NJ Hannan, L Ye, N Binder, P Cannon, L Tuohey, TG Johns, A Shub, S Tong

2015-12-01

In preeclampsia, the antiangiogenic factor soluble fms-like tyrosine kinase-1 (sFLT-1) is released from placenta into the maternal..

MMP-14 is expressed in preeclamptic placentas and mediates release of soluble endoglin

TJ Kaitu'U-Lino, KR Palmer, CL Whitehead, E Williams, M Lappas, S Tong

2012-03-01

Soluble endoglin is an anti-angiogenic protein that is released from the placenta and contributes to both maternal endothelial dys..

Ultrasound Reference Chart Based on IVF Dates to Estimate Gestational Age at 6-9 weeks' Gestation.

Pavitra Delpachitra, Kirsten Palmer, Joseph Onwude, Simon Meagher, Luk Rombauts, Karen Waalwyk, Michael Bethune, Stephen Tong

2012-01-01

Accurate determination of gestational age underpins good obstetric care. We assessed the performance of six existing ultrasound re..

Measurement of mRNA transcripts of very high placental expression in maternal blood as biomarkers of preeclampsia

P Paiva, C Whitehead, B Saglam, K Palmer, S Tong

2011-11-01

Context: mRNA of placental origin in maternal blood shows potential as a clinical biomarker of obstetric diseases such as preeclam..

Severe early-onset preeclampsia is not associated with a change in placental catechol O-methyltransferase (COMT) expression

K Palmer, B Saglam, C Whitehead, O Stock, M Lappas, S Tong

2011-01-01

The genetic deletion of catechol O-methyltransferase (COMT) in mice produces a preeclampsia-like phenotype, with mice exhibiting h..